Assay Detail
Binding
CHEMBL5149784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant renin
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.70 | 10.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390196 | — | — | 1 | 10.17 |
| CHEMBL1639 | ALISKIREN | 4.0 | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390196 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL1639 | ALISKIREN | IC50 | = | 0.6 | nM | 9.22 |