Assay Detail
Functional
CHEMBL5149848
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Agonist activity at human GLP1R expressed in frozen cells assessed as measuring the cAMP level incubated for 1 hr by by HitHunter chemiluminescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 10.00 | 10.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5186705 | — | — | 1 | 10.55 |
| CHEMBL5183317 | — | — | 1 | 10.48 |
| CHEMBL5196728 | — | — | 1 | 10.32 |
| CHEMBL5188299 | — | — | 1 | 10.22 |
| CHEMBL5182822 | — | — | 1 | 9.47 |
| CHEMBL5197522 | — | — | 1 | 8.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5186705 | — | EC50 | = | 0.028 | nM | 10.55 |
| CHEMBL5183317 | — | EC50 | = | 0.033 | nM | 10.48 |
| CHEMBL5196728 | — | EC50 | = | 0.048 | nM | 10.32 |
| CHEMBL5188299 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5182822 | — | EC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5197522 | — | EC50 | = | 1.04 | nM | 8.98 |