Assay Detail
Functional
CHEMBL5149934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aroylhydrazone Glycoconjugate Prochelators Exploit Glucose Transporter 1 (GLUT1) to Target Iron in Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.87 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.21 |
| CHEMBL5180723 | — | — | 1 | 4.92 |
| CHEMBL5188074 | — | — | 1 | 4.77 |
| CHEMBL5196995 | — | — | 1 | 4.77 |
| CHEMBL5198095 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5180723 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5188074 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5196995 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5198095 | — | IC50 | = | 22000.0 | nM | 4.66 |