Assay Detail

CHEMBL5150133

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to recombinant human KRAS (1 to 169 residues) expressed in Escherichia coli - recombinant human SOS1 (560 to 1049 residues) expressed in Escherichia coli assessed as dissociation constant

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.

Korzeniecki C, Priefer R.
Eur J Med Chem (2021) 211 : 113006 -113006
PubMed 33228976 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	7.44	7.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4535474	BAY-293	—	1	7.44

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4535474	BAY-293	Kd	=	36.0	nM	7.44