Assay Detail
Binding
CHEMBL5150152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human COLO 320DM cells harboring wild type KRAS assessed as reduction in cell viability incubated for 24 hrs in presence of MVA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COLO 320DM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.45 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285848 | MANUMYCIN A | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285848 | MANUMYCIN A | IC50 | = | 3580.0 | nM | 5.45 |