Assay Detail

CHEMBL5150158

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Functional

Antiproliferative activity against human cancer cell lines harboring wild type RAS mutation assessed as reduction in cell viability

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Cancer cell lines
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.

Korzeniecki C, Priefer R.
Eur J Med Chem (2021) 211 : 113006 -113006
PubMed 33228976 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.16	7.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL279433	L-778123 FREE BASE	1.0	1	7.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL279433	L-778123 FREE BASE	IC50	=	70.0	nM	7.16