Assay Detail
Binding
CHEMBL5150808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3-ITD (unknown origin)
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.06 | 8.15 |
| Kd | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207533 | — | — | 1 | 8.40 |
| CHEMBL5170277 | — | — | 1 | 8.15 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207533 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL5170277 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 11.0 | nM | 7.96 |