Assay Detail
Binding
CHEMBL5150899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for 3 hrs by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TR-293-KDG |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PAK 4 (CHEMBL4482) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | 1.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | IC50 | = | 1.3 | nM | 8.89 |