Assay Detail
Functional
CHEMBL5150941
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Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Emerging small-molecule inhibitors of the Bruton's tyrosine kinase (BTK): Current development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.80 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 11.00 |
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 10.85 |
| CHEMBL5200275 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3707348 | ACALABRUTINIB | IC50 | = | 0.014 | nM | 10.85 |
| CHEMBL5200275 | — | IC50 | = | 28.0 | nM | 7.55 |