Assay Detail
Binding
CHEMBL5150956
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Binding affinity to bovine brain membrane BzR assessed as inhibition constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.35 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | 4.0 | 1 | 9.07 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 9.05 |
| CHEMBL75307 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452 | CLONAZEPAM | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL12 | DIAZEPAM | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL75307 | — | Ki | = | 117.0 | nM | 6.93 |