Assay Detail
Binding
CHEMBL5150993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt signalling in human SW480 cells harbouring TCF/LEF luciferase reporter gene assessed as assessed as reduction in luciferase activity incubated for 48 hrs by Bright-Glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW480 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297639 | LORECIVIVINT | 3.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297639 | LORECIVIVINT | EC50 | = | 20.0 | nM | 7.70 |