Assay Detail

CHEMBL5150994

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Binding

Inhibition of human CLK2

ChEMBL ↗

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Target

Dual specificity protein kinase CLK2 (CHEMBL4225) ↗

Open DB target context

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Dual specificity protein kinase CLK2 (CHEMBL4225) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Dual specificity protein kinase CLK2

CHEMBL4225

Anchored from Assay target.

Protein identity Dual specificity protein kinase CLK2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Dual specificity protein kinase CLK2 (CHEMBL4225) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Bayle ED, Svensson F, Atkinson BN, Steadman D, Willis NJ, Woodward HL, Whiting P, Vincent JP, Fish PV.
J Med Chem (2021) 64 : 4289 -4311
PubMed 33783220 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.10	8.10

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4297639	LORECIVIVINT	3.0	1	8.10

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4297639	LORECIVIVINT	IC50	=	8.0	nM	8.10