Assay Detail
Binding
CHEMBL5151002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wnt/beta-catenin signaling in mouse L Wnt-3A cells assessed as reduction in Wnt3a mediated beta-catenin translocation in DKK1 stimulated cells preincubated for 1 hrs followed by Wnt-3A stimulation and measured after 2 hrs by Hoechst 33342 dye based microscopy
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L Wnt-3A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.90 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162107 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162107 | — | IC50 | = | 12600.0 | nM | 4.90 |