Assay Detail
Binding
CHEMBL5151032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of UAE (unknown origin) mediated neddylation assessed as decrease in UbcH10-Ub adduct formation incubated for 2 hrs in presence of L-glutathione and ATP by HTRF assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.80 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | 3.0 | 1 | 8.43 |
| CHEMBL5177755 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231160 | PEVONEDISTAT | IC50 | = | 3.72 | nM | 8.43 |
| CHEMBL5177755 | — | IC50 | = | 66.84 | nM | 7.17 |