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Assay Detail

CHEMBL5151300

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of cytotoxic natural products from Red Sea sponges: Structure and synthesis.
Khan S, Al-Fadhli AA, Tilvi S.
Eur J Med Chem (2021) 220 : 113491 -113491
PubMed 33940466 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.18 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1242929 1 5.57
CHEMBL1243114 1 5.57
CHEMBL1243115 1 5.52
CHEMBL404116 LATRUNCULIN A 1 5.38
CHEMBL1243079 1 5.35
CHEMBL1242955 1 5.30
CHEMBL1242983 1 5.29
CHEMBL1243047 1 5.17
CHEMBL1243080 1 5.14
CHEMBL1242956 1 4.70
CHEMBL1243390 1 4.63
CHEMBL1240669 1 4.58
CHEMBL1242982 1 -
CHEMBL1243014 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1242929 IC50 = 2710.0 nM 5.57
CHEMBL1243114 IC50 = 2720.0 nM 5.57
CHEMBL1243115 IC50 = 2990.0 nM 5.52
CHEMBL404116 LATRUNCULIN A IC50 = 4190.0 nM 5.38
CHEMBL1243079 IC50 = 4480.0 nM 5.35
CHEMBL1242955 IC50 = 5050.0 nM 5.30
CHEMBL1242983 IC50 = 5070.0 nM 5.29
CHEMBL1243047 IC50 = 6820.0 nM 5.17
CHEMBL1243080 IC50 = 7190.0 nM 5.14
CHEMBL1242956 IC50 = 19930.0 nM 4.70
CHEMBL1243390 IC50 = 23420.0 nM 4.63
CHEMBL1240669 IC50 = 26170.0 nM 4.58
CHEMBL1242982 IC50 > 50000.0 nM -
CHEMBL1243014 IC50 > 50000.0 nM -