Assay Detail
Functional
CHEMBL5151306
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Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.09 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182623 | — | — | 1 | 9.85 |
| CHEMBL5198044 | — | — | 1 | 9.32 |
| CHEMBL5192042 | — | — | 1 | 9.25 |
| CHEMBL5183877 | — | — | 1 | 9.24 |
| CHEMBL5176627 | — | — | 1 | 9.14 |
| CHEMBL5171810 | — | — | 1 | 8.83 |
| CHEMBL5206108 | — | — | 1 | 8.74 |
| CHEMBL5181118 | — | — | 1 | 8.70 |
| CHEMBL5179078 | — | — | 1 | 8.70 |
| CHEMBL5194640 | — | — | 1 | 8.59 |
| CHEMBL5184158 | — | — | 1 | 8.56 |
| CHEMBL5186863 | — | — | 1 | 8.53 |
| CHEMBL5192239 | — | — | 1 | 8.49 |
| CHEMBL5201280 | — | — | 1 | 8.47 |
| CHEMBL3326882 | — | — | 1 | 8.44 |
| CHEMBL5193826 | — | — | 1 | 8.32 |
| CHEMBL5208408 | — | — | 1 | 8.31 |
| CHEMBL5185652 | — | — | 1 | 8.29 |
| CHEMBL5185510 | — | — | 1 | 8.15 |
| CHEMBL5196008 | — | — | 1 | 7.99 |
| CHEMBL5181782 | — | — | 1 | 7.96 |
| CHEMBL5170544 | — | — | 1 | 7.86 |
| CHEMBL5200776 | — | — | 1 | 7.82 |
| CHEMBL5199708 | — | — | 1 | 7.79 |
| CHEMBL5191718 | — | — | 1 | 7.19 |
| CHEMBL5198941 | — | — | 1 | 7.13 |
| CHEMBL5193399 | — | — | 1 | 7.12 |
| CHEMBL2103835 | — | — | 1 | 7.05 |
| CHEMBL5169880 | — | — | 1 | 7.00 |
| CHEMBL5200172 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182623 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5198044 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5192042 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL5183877 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL5176627 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL5171810 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL5206108 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5181118 | — | IC50 | = | 2.01 | nM | 8.70 |
| CHEMBL5179078 | — | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL5194640 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5184158 | — | IC50 | = | 2.73 | nM | 8.56 |
| CHEMBL5186863 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL5192239 | — | IC50 | = | 3.21 | nM | 8.49 |
| CHEMBL5201280 | — | IC50 | = | 3.35 | nM | 8.47 |
| CHEMBL3326882 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5193826 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL5208408 | — | IC50 | = | 4.91 | nM | 8.31 |
| CHEMBL5185652 | — | IC50 | = | 5.16 | nM | 8.29 |
| CHEMBL5185510 | — | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL5196008 | — | IC50 | = | 10.33 | nM | 7.99 |
| CHEMBL5181782 | — | IC50 | = | 11.03 | nM | 7.96 |
| CHEMBL5170544 | — | IC50 | = | 13.82 | nM | 7.86 |
| CHEMBL5200776 | — | IC50 | = | 15.31 | nM | 7.82 |
| CHEMBL5199708 | — | IC50 | = | 16.13 | nM | 7.79 |
| CHEMBL5191718 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5198941 | — | IC50 | = | 74.01 | nM | 7.13 |
| CHEMBL5193399 | — | IC50 | = | 76.07 | nM | 7.12 |
| CHEMBL2103835 | — | IC50 | = | 88.19 | nM | 7.05 |
| CHEMBL5169880 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5200172 | — | IC50 | = | 209.5 | nM | 6.68 |
| CHEMBL2331577 | THAILANSTATIN C | IC50 | = | 298.5 | nM | 6.53 |
| CHEMBL5206472 | — | IC50 | = | 383.6 | nM | 6.42 |
| CHEMBL5176052 | — | IC50 | = | 383.6 | nM | 6.42 |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 400.0 | nM | - |
| CHEMBL5189338 | — | IC50 | > | 16.0 | nM | - |
| CHEMBL2333561 | THAILANSTATIN A | IC50 | > | 400.0 | nM | - |
| CHEMBL2333560 | THAILANSTATIN B | IC50 | > | 1000.0 | nM | - |
| CHEMBL3326877 | — | IC50 | > | 1000.0 | nM | - |