Assay Detail
Binding
CHEMBL5151554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK5/p35 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.48 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208600 | — | — | 1 | 7.19 |
| CHEMBL216543 | — | — | 1 | 7.00 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208600 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL216543 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 5500.0 | nM | 5.26 |