Assay Detail
Binding
CHEMBL5151608
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Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.62 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409450 | 6BIO | — | 1 | 8.30 |
| CHEMBL216543 | — | — | 1 | 7.66 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 6.00 |
| CHEMBL1092509 | — | — | 1 | 4.50 |
| CHEMBL5199235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409450 | 6BIO | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL216543 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1092509 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5199235 | — | IC50 | > | 100000.0 | nM | - |