Assay Detail
Functional
CHEMBL5151739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
31
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293FT |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Probable G-protein coupled receptor 174 (CHEMBL3813587) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 7.73 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205892 | — | — | 2 | 8.80 |
| CHEMBL5202832 | — | — | 2 | 7.89 |
| CHEMBL5190748 | — | — | 2 | 7.66 |
| CHEMBL1742484 | — | — | 2 | 7.47 |
| CHEMBL3577265 | — | — | 2 | 7.47 |
| CHEMBL5206394 | — | — | 2 | 7.09 |
| CHEMBL5169487 | — | — | 2 | - |
| CHEMBL5208556 | — | — | 2 | - |
| CHEMBL5196983 | — | — | 2 | - |
| CHEMBL5173365 | — | — | 1 | - |
| CHEMBL5208758 | — | — | 1 | - |
| CHEMBL5199515 | — | — | 1 | - |
| CHEMBL5192494 | — | — | 1 | - |
| CHEMBL5190878 | — | — | 1 | - |
| CHEMBL5189128 | — | — | 2 | - |
| CHEMBL5179787 | — | — | 1 | - |
| CHEMBL5183032 | — | — | 1 | - |
| CHEMBL5178904 | — | — | 1 | - |
| CHEMBL5206354 | — | — | 1 | - |
| CHEMBL5184851 | — | — | 1 | - |
| CHEMBL5180622 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205892 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5205892 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5202832 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5202832 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL5190748 | — | EC50 | = | 21.88 | nM | 7.66 |
| CHEMBL5190748 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1742484 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL3577265 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL3577265 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1742484 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5206394 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL5206394 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5196983 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5196983 | — | EC50 | > | 3162.28 | nM | - |
| CHEMBL5208556 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5169487 | — | EC50 | > | 3162.28 | nM | - |
| CHEMBL5169487 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5173365 | — | EC50 | - | — | - | |
| CHEMBL5208758 | — | EC50 | - | — | - | |
| CHEMBL5208556 | — | EC50 | > | 3162.28 | nM | - |
| CHEMBL5192494 | — | EC50 | - | — | - | |
| CHEMBL5190878 | — | EC50 | - | — | - | |
| CHEMBL5189128 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL5189128 | — | EC50 | > | 3162.28 | nM | - |
| CHEMBL5179787 | — | EC50 | - | — | - | |
| CHEMBL5183032 | — | EC50 | - | — | - | |
| CHEMBL5178904 | — | EC50 | - | — | - | |
| CHEMBL5206354 | — | EC50 | - | — | - | |
| CHEMBL5184851 | — | EC50 | - | — | - | |
| CHEMBL5180622 | — | EC50 | - | — | - | |
| CHEMBL5199515 | — | EC50 | - | — | - |