Assay Detail
Binding
CHEMBL5151869
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Inhibition of recombinant human furin using Phac-Arg-Val-Arg-Arg-AMC as substrate incubated for 30 mins and measured by microplate reader method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Why All the Fury over Furin?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 10.18 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188244 | — | — | 1 | 11.00 |
| CHEMBL5193701 | — | — | 1 | 10.88 |
| CHEMBL5205365 | — | — | 1 | 10.86 |
| CHEMBL5203853 | — | — | 1 | 10.55 |
| CHEMBL5176040 | — | — | 1 | 10.47 |
| CHEMBL5189010 | — | — | 1 | 8.90 |
| CHEMBL5170438 | — | — | 1 | 8.60 |
| CHEMBL5190391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188244 | — | Ki | = | 0.0101 | nM | 11.00 |
| CHEMBL5193701 | — | Ki | = | 0.0131 | nM | 10.88 |
| CHEMBL5205365 | — | Ki | = | 0.0138 | nM | 10.86 |
| CHEMBL5203853 | — | Ki | = | 0.0283 | nM | 10.55 |
| CHEMBL5176040 | — | Ki | = | 0.0337 | nM | 10.47 |
| CHEMBL5189010 | — | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL5170438 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL5190391 | — | Ki | = | 0.0062 | nM | - |