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Assay Detail

CHEMBL5151874

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Recombinant vaccinia-expressed furin (unknown origin) using Pyr-RTKR-MCA as substrate and measured by fluorescence based assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Furin (CHEMBL2611)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Why All the Fury over Furin?
Osman EEA, Rehemtulla A, Neamati N.
J Med Chem (2022) 65 : 2747 -2784
PubMed 34340303 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.59 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488769 1 8.22
CHEMBL485694 1 7.92
CHEMBL487946 1 7.38
CHEMBL506022 1 7.34
CHEMBL505581 1 7.16
CHEMBL5194005 1 7.05
CHEMBL205548 1 6.77
CHEMBL5196320 1 6.40
CHEMBL448513 1 6.39
CHEMBL5209516 1 5.92
CHEMBL1963286 1 5.82
CHEMBL5194189 1 5.57
CHEMBL5184649 1 5.26
CHEMBL5191784 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488769 Ki = 6.0 nM 8.22
CHEMBL485694 Ki = 12.0 nM 7.92
CHEMBL487946 Ki = 42.0 nM 7.38
CHEMBL506022 Ki = 46.0 nM 7.34
CHEMBL505581 Ki = 69.0 nM 7.16
CHEMBL5194005 Ki = 89.0 nM 7.05
CHEMBL205548 Ki = 169.0 nM 6.77
CHEMBL5196320 Ki = 400.0 nM 6.40
CHEMBL448513 Ki = 404.0 nM 6.39
CHEMBL5209516 Ki = 1200.0 nM 5.92
CHEMBL1963286 Ki = 1500.0 nM 5.82
CHEMBL5194189 Ki = 2700.0 nM 5.57
CHEMBL5184649 Ki = 5500.0 nM 5.26
CHEMBL5191784 Ki = 8300.0 nM 5.08