Assay Detail
Binding
CHEMBL5151901
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.81 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 9.89 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.30 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24828 | VANDETANIB | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL535 | SUNITINIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 5.9 | nM | 8.23 |