Assay Detail
Binding
CHEMBL5152021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.22 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 10.46 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 8.40 |
| CHEMBL2029988 | CEP-32496 | 2.0 | 1 | 7.77 |
| CHEMBL5171764 | — | — | 1 | 7.46 |
| CHEMBL4559134 | SELPERCATINIB | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2029988 | CEP-32496 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5171764 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4559134 | SELPERCATINIB | IC50 | = | 100.0 | nM | 7.00 |