Assay Detail
Binding
CHEMBL5152022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET (CHEMBL3430904) ↗| Type | CHIMERIC PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.18 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5171764 | — | — | 1 | 9.40 |
| CHEMBL2029988 | CEP-32496 | 2.0 | 1 | 8.15 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5171764 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2029988 | CEP-32496 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 34.0 | nM | 7.47 |