Assay Detail
Binding
CHEMBL5152027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET G810R (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.77 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559134 | SELPERCATINIB | 4.0 | 1 | 7.77 |
| CHEMBL5171764 | — | — | 1 | - |
| CHEMBL5095062 | ENBEZOTINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559134 | SELPERCATINIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5171764 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5095062 | ENBEZOTINIB | IC50 | > | 500.0 | nM | - |