Assay Detail

CHEMBL5152114

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Binding

Inhibition of Clostridium botulinum BoNT/A light chain using SNAPtide as substrate by HPLC assay

ChEMBL ↗

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Target

Botulinum neurotoxin type A (CHEMBL5192) ↗

Open DB target context

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Loading context

Botulinum neurotoxin type A (CHEMBL5192) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Botulinum neurotoxin type A

CHEMBL5192

Anchored from Assay target.

Protein identity Botulinum neurotoxin type A

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Clostridium botulinum
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Botulinum neurotoxin type A (CHEMBL5192) ↗

Type	SINGLE PROTEIN
Organism	Clostridium botulinum

Publication

Zinc enzymes in medicinal chemistry.

Hou R, He Y, Yan G, Hou S, Xie Z, Liao C.
Eur J Med Chem (2021) 226 : 113877 -113877
PubMed 34624823 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL237370	CINNAMIC ACID HYDROXAMATE	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL237370	CINNAMIC ACID HYDROXAMATE	IC50	=	400.0	nM	6.40