Assay Detail
Binding
CHEMBL5152168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/PR/8/1934 (H1N1) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.06 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181864 | — | — | 1 | 9.14 |
| CHEMBL4287425 | — | — | 1 | 8.73 |
| CHEMBL5172128 | — | — | 1 | 8.43 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.29 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.95 |
| CHEMBL5207634 | — | — | 1 | 7.84 |
| CHEMBL5193354 | — | — | 1 | 7.72 |
| CHEMBL5181442 | — | — | 1 | 7.62 |
| CHEMBL3342478 | — | — | 1 | 7.54 |
| CHEMBL5182201 | — | — | 1 | 6.78 |
| CHEMBL5196520 | — | — | 1 | 6.60 |
| CHEMBL5207047 | — | — | 1 | 6.54 |
| CHEMBL5186671 | — | — | 1 | 6.41 |
| CHEMBL5192559 | — | — | 1 | 6.39 |
| CHEMBL5185151 | — | — | 1 | 6.38 |
| CHEMBL5190380 | — | — | 1 | 6.31 |
| CHEMBL5189152 | — | — | 1 | 6.10 |
| CHEMBL5173999 | — | — | 1 | 5.68 |
| CHEMBL5208577 | — | — | 1 | 5.50 |
| CHEMBL5197852 | — | — | 1 | 5.27 |
| CHEMBL5186387 | — | — | 1 | - |
| CHEMBL5186800 | — | — | 1 | - |
| CHEMBL5207060 | — | — | 1 | - |
| CHEMBL5173578 | — | — | 1 | - |
| CHEMBL5183073 | — | — | 1 | - |
| CHEMBL5171468 | — | — | 1 | - |
| CHEMBL5172394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181864 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4287425 | — | IC50 | = | 1.88 | nM | 8.73 |
| CHEMBL5172128 | — | IC50 | = | 3.72 | nM | 8.43 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 5.16 | nM | 8.29 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 11.25 | nM | 7.95 |
| CHEMBL5207634 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL5193354 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL5181442 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL3342478 | — | IC50 | = | 28.59 | nM | 7.54 |
| CHEMBL5182201 | — | IC50 | = | 167.3 | nM | 6.78 |
| CHEMBL5196520 | — | IC50 | = | 251.8 | nM | 6.60 |
| CHEMBL5207047 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL5186671 | — | IC50 | = | 388.6 | nM | 6.41 |
| CHEMBL5192559 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5185151 | — | IC50 | = | 421.3 | nM | 6.38 |
| CHEMBL5190380 | — | IC50 | = | 490.6 | nM | 6.31 |
| CHEMBL5189152 | — | IC50 | = | 802.0 | nM | 6.10 |
| CHEMBL5173999 | — | IC50 | = | 2069.6 | nM | 5.68 |
| CHEMBL5208577 | — | IC50 | = | 3186.3 | nM | 5.50 |
| CHEMBL5197852 | — | IC50 | = | 5363.0 | nM | 5.27 |
| CHEMBL5186387 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5186800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5207060 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5173578 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5183073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5171468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172394 | — | IC50 | > | 10000.0 | nM | - |