Assay Detail
Binding
CHEMBL5152169
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Inhibition of Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.29 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207634 | — | — | 1 | 9.80 |
| CHEMBL5181864 | — | — | 1 | 9.57 |
| CHEMBL5172128 | — | — | 1 | 9.06 |
| CHEMBL4287425 | — | — | 1 | 9.03 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.63 |
| CHEMBL5181442 | — | — | 1 | 8.43 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.35 |
| CHEMBL5193354 | — | — | 1 | 7.98 |
| CHEMBL3342478 | — | — | 1 | 7.82 |
| CHEMBL5192559 | — | — | 1 | 7.68 |
| CHEMBL5185151 | — | — | 1 | 7.40 |
| CHEMBL5182201 | — | — | 1 | 7.13 |
| CHEMBL5173999 | — | — | 1 | 7.03 |
| CHEMBL5196520 | — | — | 1 | 6.89 |
| CHEMBL5207047 | — | — | 1 | 6.67 |
| CHEMBL5208577 | — | — | 1 | 6.29 |
| CHEMBL5186671 | — | — | 1 | 6.23 |
| CHEMBL5189152 | — | — | 1 | 6.03 |
| CHEMBL5190380 | — | — | 1 | 5.92 |
| CHEMBL5171468 | — | — | 1 | 5.90 |
| CHEMBL5186387 | — | — | 1 | 5.87 |
| CHEMBL5207060 | — | — | 1 | 5.81 |
| CHEMBL5173578 | — | — | 1 | 5.72 |
| CHEMBL5197852 | — | — | 1 | 5.68 |
| CHEMBL5186800 | — | — | 1 | - |
| CHEMBL5183073 | — | — | 1 | - |
| CHEMBL5172394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207634 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5181864 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL5172128 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL4287425 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 2.35 | nM | 8.63 |
| CHEMBL5181442 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 4.47 | nM | 8.35 |
| CHEMBL5193354 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL3342478 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL5192559 | — | IC50 | = | 20.76 | nM | 7.68 |
| CHEMBL5185151 | — | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL5182201 | — | IC50 | = | 74.7 | nM | 7.13 |
| CHEMBL5173999 | — | IC50 | = | 92.8 | nM | 7.03 |
| CHEMBL5196520 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5207047 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5208577 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL5186671 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL5189152 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5190380 | — | IC50 | = | 1196.0 | nM | 5.92 |
| CHEMBL5171468 | — | IC50 | = | 1271.0 | nM | 5.90 |
| CHEMBL5186387 | — | IC50 | = | 1347.0 | nM | 5.87 |
| CHEMBL5207060 | — | IC50 | = | 1558.0 | nM | 5.81 |
| CHEMBL5173578 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5197852 | — | IC50 | = | 2064.0 | nM | 5.68 |
| CHEMBL5186800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5183073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172394 | — | IC50 | > | 10000.0 | nM | - |