Assay Detail
Binding
CHEMBL5152170
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Inhibition of Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) neuraminidase using using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.85 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5181864 | — | — | 1 | 9.20 |
| CHEMBL4287425 | — | — | 1 | 9.08 |
| CHEMBL5207634 | — | — | 1 | 8.78 |
| CHEMBL5172128 | — | — | 1 | 8.24 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.16 |
| CHEMBL5193354 | — | — | 1 | 8.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.47 |
| CHEMBL3342478 | — | — | 1 | 7.38 |
| CHEMBL5181442 | — | — | 1 | 7.30 |
| CHEMBL5196520 | — | — | 1 | 7.29 |
| CHEMBL5207047 | — | — | 1 | 6.98 |
| CHEMBL5192559 | — | — | 1 | 6.82 |
| CHEMBL5190380 | — | — | 1 | 6.67 |
| CHEMBL5182201 | — | — | 1 | 6.47 |
| CHEMBL5208577 | — | — | 1 | 6.41 |
| CHEMBL5173999 | — | — | 1 | 6.11 |
| CHEMBL5189152 | — | — | 1 | 5.87 |
| CHEMBL5173578 | — | — | 1 | 5.85 |
| CHEMBL5197852 | — | — | 1 | 5.83 |
| CHEMBL5186671 | — | — | 1 | 5.82 |
| CHEMBL5207060 | — | — | 1 | 5.74 |
| CHEMBL5186800 | — | — | 1 | 5.70 |
| CHEMBL5185151 | — | — | 1 | 5.67 |
| CHEMBL5183073 | — | — | 1 | 5.27 |
| CHEMBL5186387 | — | — | 1 | 5.26 |
| CHEMBL5171468 | — | — | 1 | - |
| CHEMBL5172394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5181864 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4287425 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL5207634 | — | IC50 | = | 1.68 | nM | 8.78 |
| CHEMBL5172128 | — | IC50 | = | 5.81 | nM | 8.24 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5193354 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 34.08 | nM | 7.47 |
| CHEMBL3342478 | — | IC50 | = | 41.4 | nM | 7.38 |
| CHEMBL5181442 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL5196520 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5207047 | — | IC50 | = | 104.5 | nM | 6.98 |
| CHEMBL5192559 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5190380 | — | IC50 | = | 212.9 | nM | 6.67 |
| CHEMBL5182201 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL5208577 | — | IC50 | = | 390.6 | nM | 6.41 |
| CHEMBL5173999 | — | IC50 | = | 768.5 | nM | 6.11 |
| CHEMBL5189152 | — | IC50 | = | 1358.0 | nM | 5.87 |
| CHEMBL5173578 | — | IC50 | = | 1419.0 | nM | 5.85 |
| CHEMBL5197852 | — | IC50 | = | 1493.0 | nM | 5.83 |
| CHEMBL5186671 | — | IC50 | = | 1499.0 | nM | 5.82 |
| CHEMBL5207060 | — | IC50 | = | 1813.3 | nM | 5.74 |
| CHEMBL5186800 | — | IC50 | = | 1993.6 | nM | 5.70 |
| CHEMBL5185151 | — | IC50 | = | 2158.0 | nM | 5.67 |
| CHEMBL5183073 | — | IC50 | = | 5335.0 | nM | 5.27 |
| CHEMBL5186387 | — | IC50 | = | 5439.7 | nM | 5.26 |
| CHEMBL5171468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5172394 | — | IC50 | > | 10000.0 | nM | - |