Assay Detail
Binding
CHEMBL5152176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/Anhui/1/2005 (H5N1) Neuraminidase H274Y mutant using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as substrate preincubated for 10 mins followed by substrate addition and measured after 40 mins by fluorescence based microplate reader method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.31 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.02 |
| CHEMBL5207634 | — | — | 1 | 5.36 |
| CHEMBL5181864 | — | — | 1 | 5.19 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.08 |
| CHEMBL5193354 | — | — | 1 | 4.67 |
| CHEMBL5172128 | — | — | 1 | 4.58 |
| CHEMBL5181442 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5207634 | — | IC50 | = | 4370.0 | nM | 5.36 |
| CHEMBL5181864 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL5193354 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL5172128 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL5181442 | — | IC50 | = | 51300.0 | nM | 4.29 |