Assay Detail
Functional
CHEMBL5152180
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Antiviral activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chick embryo fibroblast assessed as reduction in virus-induced cytopathic effect measured for 48 hrs by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | CEF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.74 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207634 | — | — | 1 | 6.29 |
| CHEMBL5181864 | — | — | 1 | 6.24 |
| CHEMBL5172128 | — | — | 1 | 5.52 |
| CHEMBL5181442 | — | — | 1 | 5.50 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.17 |
| CHEMBL5193354 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207634 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5181864 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5172128 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5181442 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL5193354 | — | EC50 | > | 10000.0 | nM | - |