Assay Detail
Functional
CHEMBL5152184
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Antiviral activity against Influenza A virus A/PR/8/34 (H1N1) infected in dog MDCK cells assessed as inhibition of plaque formation incubated for 2 days by plaque reduction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of C5-NH<sub>2</sub> Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.50 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207634 | — | — | 1 | 8.00 |
| CHEMBL5181864 | — | — | 1 | 7.70 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.70 |
| CHEMBL5181442 | — | — | 1 | 7.40 |
| CHEMBL5172128 | — | — | 1 | 7.40 |
| CHEMBL5193354 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207634 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5181864 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5181442 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5172128 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5193354 | — | EC50 | = | 170.0 | nM | 6.77 |