Assay Detail
Binding
CHEMBL5152302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of S1PR1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.51 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205276 | — | — | 1 | 8.17 |
| CHEMBL5183923 | — | — | 1 | 7.85 |
| CHEMBL5200777 | — | — | 1 | 7.81 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205276 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5183923 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5200777 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 603.75 | nM | 6.22 |