Assay Detail

CHEMBL5152368

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Functional

Anticancer activity against human NCI-H446 cells assessed as cell growth inhibition

ChEMBL ↗

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Target

NCI-H446 (CHEMBL612440) ↗

Open DB target context

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Primary target NCI-H446

CHEMBL612440

Anchored from Assay target.

Protein identity NCI-H446

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H446
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H446 (CHEMBL612440) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs.

Singh SB.
J Nat Prod (2022) 85 : 666 -687
PubMed 35072477 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.49	10.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39541	DOLASTATIN-10	2.0	1	10.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39541	DOLASTATIN-10	IC50	=	0.032	nM	10.49