Assay Detail

CHEMBL5152389

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Functional

Anticancer activity against human HT-29 assessed as reduction in cell viability incubated for 96 hrs by microculture tetrazolium assay

ChEMBL ↗

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Target

HT-29 (CHEMBL384) ↗

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HT-29 (CHEMBL384) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HT-29

CHEMBL384

Anchored from Assay target.

Protein identity HT-29

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-29
Confidence	1 — Organism
Curated By	Autocuration

Target

HT-29 (CHEMBL384) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs.

Singh SB.
J Nat Prod (2022) 85 : 666 -687
PubMed 35072477 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.73	10.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39541	DOLASTATIN-10	2.0	1	10.22
CHEMBL5209850	—	—	1	7.23

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39541	DOLASTATIN-10	IC50	=	0.06	nM	10.22
CHEMBL5209850	—	IC50	=	58.5	nM	7.23