Assay Detail
Binding
CHEMBL5152397
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Inhibition of DPP4 (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.29 | 7.66 |
| Ki | 2 | 5.04 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 7.66 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 6.92 |
| CHEMBL387444 | — | — | 1 | 5.04 |
| CHEMBL189620 | — | — | 1 | - |
| CHEMBL1243126 | — | — | 1 | - |
| CHEMBL2022530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL387444 | — | Ki | = | 9080.0 | nM | 5.04 |
| CHEMBL189620 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL1243126 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2022530 | — | Ki | > | 100000.0 | nM | - |