Assay Detail

CHEMBL5152491

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Binding

Binding affinity to ERK1 (unknown origin)

ChEMBL ↗

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Target

Mitogen-activated protein kinase 3 (CHEMBL3385) ↗

Open DB target context

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Mitogen-activated protein kinase 3 (CHEMBL3385) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mitogen-activated protein kinase 3

CHEMBL3385

Anchored from Assay target.

Protein identity Mitogen-activated protein kinase 3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Mitogen-activated protein kinase 3 (CHEMBL3385) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors.

Fu L, Chen S, He G, Chen Y, Liu B.
J Med Chem (2022) 65 : 13561 -13573
PubMed 36205714 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.19	9.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4650285	TEMUTERKIB	2.0	1	9.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4650285	TEMUTERKIB	Ki	=	0.65	nM	9.19