Assay Detail
Binding
CHEMBL5152492
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Inhibition of equine liver glutathione S-transferase using GSH and CDNB as substrate preincubated for 5 mins followed by substrate addition and measured in the absence of UV irradiation by spectrophotometric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178537 | — | — | 1 | 6.05 |
| CHEMBL5169380 | — | — | 1 | 6.04 |
| CHEMBL5203780 | — | — | 1 | 5.27 |
| CHEMBL456 | ETHACRYNIC ACID | 4.0 | 1 | 5.23 |
| CHEMBL5184218 | — | — | 1 | 4.78 |
| CHEMBL5174343 | — | — | 1 | 4.73 |
| CHEMBL5199600 | — | — | 1 | 4.58 |
| CHEMBL5201291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178537 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5169380 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5203780 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL456 | ETHACRYNIC ACID | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL5184218 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5174343 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5199600 | — | IC50 | = | 26240.0 | nM | 4.58 |
| CHEMBL5201291 | — | IC50 | > | 25000.0 | nM | - |