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Assay Detail

CHEMBL5152637

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers.
Reiland KM, Eckroat TJ.
Bioorg Med Chem Lett (2022) 77 : 129037 -129037
PubMed 36307033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 8.73 8.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL95 TACRINE 4.0 1 8.73
CHEMBL373781 1 -
CHEMBL4281415 1 -
CHEMBL4289287 1 -
CHEMBL4288425 1 -
CHEMBL4280199 1 -
CHEMBL5199882 1 -
CHEMBL4284919 1 -
CHEMBL5183229 1 -
CHEMBL5176734 1 -
CHEMBL5206401 1 -
CHEMBL5193420 1 -
CHEMBL5191589 1 -
CHEMBL5195794 1 -
CHEMBL3322358 1 -
CHEMBL326294 ISATIN 1 -
CHEMBL636 RIVASTIGMINE 4.0 1 -
CHEMBL5185973 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL95 TACRINE IC50 = 1.87 nM 8.73
CHEMBL373781 IC50 > 125000.0 nM -
CHEMBL4281415 IC50 > 125000.0 nM -
CHEMBL4289287 IC50 > 125000.0 nM -
CHEMBL4288425 IC50 > 50000.0 nM -
CHEMBL4280199 IC50 > 50000.0 nM -
CHEMBL5199882 IC50 > 50000.0 nM -
CHEMBL4284919 IC50 > 50000.0 nM -
CHEMBL5183229 IC50 > 50000.0 nM -
CHEMBL5176734 IC50 > 50000.0 nM -
CHEMBL5206401 IC50 > 50000.0 nM -
CHEMBL5193420 IC50 > 50000.0 nM -
CHEMBL5191589 IC50 > 50000.0 nM -
CHEMBL5195794 IC50 > 50000.0 nM -
CHEMBL3322358 IC50 = 1305000.0 nM -
CHEMBL326294 ISATIN IC50 > 1000000.0 nM -
CHEMBL636 RIVASTIGMINE IC50 = 275000.0 nM -
CHEMBL5185973 IC50 > 50000.0 nM -