Assay Detail
Binding
CHEMBL5152644
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Inhibition of recombinant human MAO-B using using kynuramine as substrate assessed as inhibition of 4-hydroxyquinoline formation incubated for 20 mins by fluorescence spectrophotometric analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The inhibition of monoamine oxidase by 2H-1,4-benzothiazin-3(4H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.76 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199383 | — | — | 1 | 8.57 |
| CHEMBL5174857 | — | — | 1 | 8.39 |
| CHEMBL5203446 | — | — | 1 | 8.09 |
| CHEMBL5174014 | — | — | 1 | 8.02 |
| CHEMBL5194774 | — | — | 1 | 7.70 |
| CHEMBL5175823 | — | — | 1 | 7.62 |
| CHEMBL5176809 | — | — | 1 | 7.15 |
| CHEMBL5170948 | — | — | 1 | 6.78 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.59 |
| CHEMBL5199502 | — | — | 1 | 5.54 |
| CHEMBL326294 | ISATIN | — | 1 | 5.41 |
| CHEMBL5180307 | — | — | 1 | 4.70 |
| CHEMBL103879 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199383 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5174857 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5203446 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL5174014 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL5194774 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5175823 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5176809 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5170948 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5199502 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL326294 | ISATIN | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5180307 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL103879 | — | IC50 | = | 42600.0 | nM | 4.37 |