Assay Detail
Functional
CHEMBL5152800
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs in presence of TTR by CellTiter-96 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enhancing the Safety and Efficacy of PSMA-Based Small-Molecule Drug Conjugates by Linker Stabilization and Conjugation to Transthyretin Binding Ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.86 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103835 | — | — | 1 | 9.00 |
| CHEMBL5178326 | — | — | 1 | 6.28 |
| CHEMBL5180672 | — | — | 1 | 6.09 |
| CHEMBL5174982 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103835 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5178326 | — | IC50 | = | 524.76 | nM | 6.28 |
| CHEMBL5180672 | — | IC50 | = | 815.83 | nM | 6.09 |
| CHEMBL5174982 | — | IC50 | = | 893.21 | nM | 6.05 |