Assay Detail
Functional
CHEMBL5152904
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Anti-necroptic activity in human HT-29 cells
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.23 | 7.82 |
| EC50 | 2 | 6.78 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061975 | — | — | 1 | 7.82 |
| CHEMBL4464023 | — | — | 1 | 7.64 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 6.06 |
| CHEMBL4453780 | — | — | 1 | 5.92 |
| CHEMBL4747732 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061975 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4464023 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 873.0 | nM | 6.06 |
| CHEMBL4453780 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4747732 | — | IC50 | = | 15000.0 | nM | 4.82 |