Assay Detail
Binding
CHEMBL5152911
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Binding affinity to RIPK1 (unknown origin) by Kinomescan method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.77 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189354 | — | — | 1 | 7.72 |
| CHEMBL188381 | GW806742X | — | 1 | 7.19 |
| CHEMBL5182551 | — | — | 1 | 7.11 |
| CHEMBL4540715 | — | — | 1 | 7.00 |
| CHEMBL5209456 | — | — | 1 | 4.82 |
| CHEMBL5191964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189354 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL188381 | GW806742X | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL5182551 | — | Kd | = | 78.0 | nM | 7.11 |
| CHEMBL4540715 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL5209456 | — | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL5191964 | — | Kd | > | 5000.0 | nM | - |