Assay Detail
Binding
CHEMBL5152913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length human MLKL pseudokinase domain by Kinomescan method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mixed lineage kinase domain-like protein (CHEMBL1938217) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.02 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188381 | GW806742X | — | 1 | 6.28 |
| CHEMBL189354 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188381 | GW806742X | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL189354 | — | Kd | = | 1800.0 | nM | 5.75 |