Assay Detail
Functional
CHEMBL5152928
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Anti-necrotic activity in human U-937 cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 9.47 |
| EC50 | 1 | 9.32 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5173634 | — | — | 1 | 9.47 |
| CHEMBL5186077 | — | — | 1 | 9.32 |
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 8.20 |
| CHEMBL3109212 | — | — | 1 | 7.80 |
| CHEMBL3108785 | — | — | 1 | 6.80 |
| CHEMBL247228 | GW770249X | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5173634 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5186077 | — | EC50 | = | 0.4826 | nM | 9.32 |
| CHEMBL4071864 | GSK2982772 | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3109212 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3108785 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL247228 | GW770249X | IC50 | = | 250.0 | nM | 6.60 |