Assay Detail
Binding
CHEMBL5152935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RIPK1 kinase domain (unknown origin) (1 to 312 domain) incubated for 30 mins in presence of ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-Molecule Receptor-Interacting Protein 1 (RIP1) Inhibitors as Therapeutic Agents for Multifaceted Diseases: Current Medicinal Chemistry Insights and Emerging Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.43 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370438 | — | — | 1 | 6.50 |
| CHEMBL259796 | — | — | 1 | 6.43 |
| CHEMBL5198153 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370438 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL259796 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5198153 | — | IC50 | = | 440.0 | nM | 6.36 |