Assay Detail
Binding
CHEMBL5152971
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Inhibition of Escherichia coli GroEL expressed in NEB-5-alpha Escherichia coli cells/Escherichia coli GroES expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of GroEL/ES-mediated dMDH refolding by reporter analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.20 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178695 | — | — | 1 | 6.39 |
| CHEMBL5209316 | — | — | 1 | 6.15 |
| CHEMBL3115912 | — | — | 1 | 6.14 |
| CHEMBL3115914 | — | — | 1 | 5.70 |
| CHEMBL5177265 | — | — | 1 | 5.68 |
| CHEMBL5170692 | — | — | 1 | 5.42 |
| CHEMBL5202538 | — | — | 1 | 5.37 |
| CHEMBL1927391 | — | — | 1 | 5.23 |
| CHEMBL3115924 | — | — | 1 | 5.17 |
| CHEMBL7976 | CHALCONE | — | 1 | 5.15 |
| CHEMBL187926 | — | — | 1 | 5.03 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | — | 1 | 4.89 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | 4.70 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | 4.70 |
| CHEMBL5185585 | — | — | 1 | 4.68 |
| CHEMBL105496 | 4-METHOXY CHALCONE | — | 1 | 4.57 |
| CHEMBL1578953 | — | — | 1 | 4.39 |
| CHEMBL463017 | — | — | 1 | 4.24 |
| CHEMBL207313 | — | — | 1 | - |
| CHEMBL5185073 | — | — | 1 | - |
| CHEMBL490512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178695 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5209316 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3115912 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3115914 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5177265 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5170692 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5202538 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1927391 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3115924 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL7976 | CHALCONE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL187926 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL34398 | 4'-METHOXYCHALCONE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5185585 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL105496 | 4-METHOXY CHALCONE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1578953 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL463017 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL207313 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5185073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL490512 | — | IC50 | > | 100000.0 | nM | - |