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Assay Detail

CHEMBL5153014

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human L3.6pl cells cells assessed as inhibition of cell growth measured after 72 hrs by ATPlite assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type L3.6pl
Confidence 1 — Organism
Curated By Autocuration

Target

L3.6pl (CHEMBL4630703)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function.
Dobrovolskaite A, Moots H, Tantak MP, Shah K, Thomas J, Dinara S, Massaro C, Hershberger PM, Maloney PR, Peddibhotla S, Sugarman E, Litherland S, Arnoletti JP, Jha RK, Levens D, Phanstiel O.
J Med Chem (2022) 65 : 15391 -15415
PubMed 36382923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.52 4.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5186405 1 4.88
CHEMBL5200143 1 4.78
CHEMBL5190346 1 4.64
CHEMBL5172811 1 4.54
CHEMBL5201143 1 4.41
CHEMBL5170852 1 4.40
CHEMBL5169628 1 4.33
CHEMBL5176947 1 4.21
CHEMBL5176142 1 -
CHEMBL5172529 1 -
CHEMBL5186864 1 -
CHEMBL5169986 1 -
CHEMBL5190208 1 -
CHEMBL5199868 1 -
CHEMBL5182850 1 -
CHEMBL5173338 1 -
CHEMBL5171008 1 -
CHEMBL5180623 1 -
CHEMBL5170137 1 -
CHEMBL5185410 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5186405 IC50 = 13300.0 nM 4.88
CHEMBL5200143 IC50 = 16800.0 nM 4.78
CHEMBL5190346 IC50 = 22900.0 nM 4.64
CHEMBL5172811 IC50 = 29100.0 nM 4.54
CHEMBL5201143 IC50 = 38600.0 nM 4.41
CHEMBL5170852 IC50 = 39900.0 nM 4.40
CHEMBL5169628 IC50 = 46300.0 nM 4.33
CHEMBL5176947 IC50 = 61600.0 nM 4.21
CHEMBL5176142 IC50 = 124800.0 nM -
CHEMBL5172529 IC50 > 30000.0 nM -
CHEMBL5186864 IC50 > 20000.0 nM -
CHEMBL5169986 IC50 > 10000.0 nM -
CHEMBL5190208 IC50 > 10000.0 nM -
CHEMBL5199868 IC50 > 100000.0 nM -
CHEMBL5182850 IC50 > 100000.0 nM -
CHEMBL5173338 IC50 > 10000.0 nM -
CHEMBL5171008 IC50 > 10000.0 nM -
CHEMBL5180623 IC50 > 10000.0 nM -
CHEMBL5170137 IC50 > 50000.0 nM -
CHEMBL5185410 IC50 > 10000.0 nM -