Assay Detail
Binding
CHEMBL5153089
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of methicillin-resistant Staphylococcus aureus ProRS expressed in Escherichia coli assessed as generation of inorganic monophosphate by pre-transfer editing-based experiment
23
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.55 | 6.75 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178546 | — | — | 1 | 6.75 |
| CHEMBL5198446 | — | — | 1 | 6.29 |
| CHEMBL5204189 | — | — | 1 | 6.21 |
| CHEMBL5202024 | — | — | 1 | 6.20 |
| CHEMBL1197091 | HALOFUGINONE | 2.0 | 2 | 6.18 |
| CHEMBL5198235 | — | — | 1 | 5.89 |
| CHEMBL5191204 | — | — | 1 | 5.77 |
| CHEMBL5184075 | — | — | 1 | 5.25 |
| CHEMBL5171655 | — | — | 1 | 5.17 |
| CHEMBL5196902 | — | — | 1 | 5.09 |
| CHEMBL5187091 | — | — | 1 | 4.91 |
| CHEMBL5186292 | — | — | 1 | 4.75 |
| CHEMBL5198720 | — | — | 1 | 4.74 |
| CHEMBL5208666 | — | — | 1 | 4.44 |
| CHEMBL5197831 | — | — | 1 | - |
| CHEMBL5180305 | — | — | 1 | - |
| CHEMBL5189534 | — | — | 1 | - |
| CHEMBL5209504 | — | — | 1 | - |
| CHEMBL5204632 | — | — | 1 | - |
| CHEMBL5189821 | — | — | 1 | - |
| CHEMBL5174207 | — | — | 1 | - |
| CHEMBL5200681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178546 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5198446 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5204189 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5202024 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1197091 | HALOFUGINONE | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5198235 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5191204 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL5184075 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL5171655 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5196902 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5187091 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL5186292 | — | IC50 | = | 17630.0 | nM | 4.75 |
| CHEMBL5198720 | — | IC50 | = | 18320.0 | nM | 4.74 |
| CHEMBL5208666 | — | IC50 | = | 36330.0 | nM | 4.44 |
| CHEMBL5197831 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5180305 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5189534 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5209504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5204632 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5189821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5174207 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5200681 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1197091 | HALOFUGINONE | Inhibition | - | % | - |