Assay Detail
Binding
CHEMBL5153100
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Binding affinity to methicillin-resistant Staphylococcus aureus ProRS expressed in Escherichia coli assessed as dissociation constant in presence of 0.2 nM ATP by microscale thermophoresis assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.01 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178546 | — | — | 1 | 5.08 |
| CHEMBL1197091 | HALOFUGINONE | 2.0 | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178546 | — | Kd | = | 8330.0 | nM | 5.08 |
| CHEMBL1197091 | HALOFUGINONE | Kd | = | 11600.0 | nM | 4.94 |